Braña, Alfredo FSarmiento-Vizcaíno, AidaPérez-Victoria, IgnacioOtero, LuisFernández, JonathanPalacios, Juan JoséMartín, Jesúsde la Cruz, MercedesDíaz, CaridadVicente, FranciscaReyes, FernandoGarcía, Luis ABlanco, Gloria2023-01-252023-01-252017-02-07http://hdl.handle.net/10668/10849Two new antibiotics, branimycins B (2) and C (3), were produced by fermentation of the abyssal actinobacterium Pseudonocardia carboxydivorans M-227, isolated from deep seawater of the Avilés submarine Canyon. Their structures were elucidated by HRMS and NMR analyses. These compounds exhibit antibacterial activities against a panel of Gram-positive bacteria, including Corynebacterium urealyticum, Clostridium perfringens, and Micrococcus luteus, and against the Gram-negative bacterium Neisseria meningitidis. Additionally, branimycin B displayed moderate antibacterial activity against other Gram-negative bacteria such as Bacteroides fragilis, Haemophilus influenzae, and Escherichia coli, and branimycin C against the Gram-positive Enterococcus faecalis and methicillin-sensitive and methicillin-resistant Staphylococcus aureus.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Anti-Bacterial AgentsEnterococcus faecalisGram-Negative BacteriaGram-Positive BacteriaHaemophilus influenzaeMacrolidesMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular StructureNuclear Magnetic Resonance, Biomolecularresearch article28169531open access10.1021/acs.jnatprod.6b011071520-6025https://digibuo.uniovi.es/dspace/bitstream/10651/42955/1/proofs%20branimycins%20B%20and%20C%20.pdf