Sampedro-Piquero, PatriciaMillón, CarmeloMoreno-Fernández, Román D.García-Fernández, MaríaDiaz-Cabiale, ZaidaSantin, Luis Javier2022-08-052022-08-052020-08-20Sampedro-Piquero P, Millón C, Moreno-Fernández RD, García-Fernández M, Diaz-Cabiale Z, Santin LJ. Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice. Brain Sci. 2020 Aug 20;10(9):576http://hdl.handle.net/10668/3888The binge-drinking pattern of EtOH consumption, which is frequently observed in adolescents, is known to induce several neurobehavioral alterations, but protection strategies against these impairments remain scarcely explored. We aimed to study the protective role of treadmill physical exercise on the deficits caused after repeated cycles of binge-like EtOH exposure in the cognition, motivation, exploration, and emotion of C57BL/6J mice from adolescence to adulthood. Animals were divided into four groups: control group, exercised group, EtOH group, and exercised + EtOH group (20% in tap water). The exercise was performed for 20 min, 5 days/week at 20 cm/s. Then, animals were submitted to several behavioral tasks. Compared to binge-drinking mice, the exercised + EtOH group exhibited diminished anxiolytic-related behaviors in the elevated plus-maze, enhanced exploratory activity in the open field, reduced preference for alcohol odor when another rewarding stimulus was present (social stimulus) and lower latency to start self-cleaning behaviors in the sucrose splash test. In contrast, other measurements such as habituation learning and working memory were not improved by exercise. Besides, exercise was not able to reduce alcohol consumption across the weeks. In conclusion, physical activity during adolescence and early adulthood could buffer certain neurobehavioral alterations associated with binge-drinking, despite not reducing the quantity of consumed alcohol.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/AdolescenceAerobic exerciseAlcoholBehaviorDrinking in the darkMiceAdolescenteEjercicio físicoEtanolConductaRatonesTrastornos inducidos por alcoholMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::MiceMedical Subject Headings::Organisms::Eukaryota::AnimalsMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Central Nervous System Depressants::Tranquilizing Agents::Anti-Anxiety AgentsMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Memory::Memory, Short-TermMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design::Control GroupsMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Nervous System Physiological Processes::Habituation, PsychophysiologicMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::MotivationMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity::ExerciseMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::CognitionMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::EmotionsMedical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Oligosaccharides::Disaccharides::SucroseMedical Subject Headings::Diseases::Chemically-Induced Disorders::Substance-Related Disorders::Alcohol-Related Disorders::AlcoholismMedical Subject Headings::Diseases::Chemically-Induced Disorders::Substance-Related Disorders::Alcohol-Related Disorders::Alcohol-Induced Disordersresearch article32825478Acceso abierto10.3390/brainsci100905762076-3425PMC7563508