Garcia-Junco-Clemente, PabloIkrar, TarunaTring, ElaineXu, XiangminRingach, Dario LTrachtenberg, Joshua T2023-01-252023-01-252017-01-23Garcia-Junco-Clemente P, Ikrar T, Tring E, Xu X, Ringach DL, Trachtenberg JT. An inhibitory pull-push circuit in frontal cortex. Nat Neurosci. 2017 Mar;20(3):389-392.http://hdl.handle.net/10668/10797Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feedback pull-push influence on excitatory neurons-an inversion of the canonical push-pull of feedforward input.enNeural circuitsCellular neuroscienceAnimalsArousalChannelrhodopsinsFeedback, PhysiologicalFemaleFrontal LobeInterneuronsLocomotionMaleMiceMice, TransgenicNeural InhibitionPupilPyramidal CellsVasoactive Intestinal Peptideresearch article28114295Restricted AccessCélulas piramidalesNivel de alertaCélulasLóbulo frontalNeuronasRetroalimentaciónInterneuronasPéptido intestinal vasoactivo10.1038/nn.44831546-1726PMC5967235https://europepmc.org/articles/pmc5967235?pdf=renderhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967235/pdf