Vázquez Morón, Juan MaríaPallarés Manrique, HéctorMachancoses, Francisco HRamos Lora, ManuelRuiz Frutos, Carlos2023-01-252023-01-2520171130-0108http://hdl.handle.net/10668/10760Fecal biomarkers, especially fecal calprotectin, are useful for predicting endoscopic activity in Crohn's disease; however, the cut-off point remains unclear. The aim of this paper was to analyze whether faecal calprotectin and M2 pyruvate kinase are good tools for generating highly accurate scores for the prediction of the state of endoscopic activity and mucosal healing. The simple endoscopic score for Crohn's disease and the Crohn's disease activity index was calculated for 71 patients diagnosed with Crohn's. Fecal calprotectin and M2-PK were measured by the enzyme-linked immunosorbent assay test. A fecal calprotectin cut-off concentration of ≥ 170 µg/g (sensitivity 77.6%, specificity 95.5% and likelihood ratio +17.06) predicts a high probability of endoscopic activity, and a fecal calprotectin cut-off of ≤ 71 µg/g (sensitivity 95.9%, specificity 52.3% and likelihood ratio -0.08) predicts a high probability of mucosal healing. Three clinical groups were identified according to the data obtained: endoscopic activity (calprotectin ≥ 170), mucosal healing (calprotectin ≤ 71) and uncertainty (71 > calprotectin calprotectin The highly accurate scores for fecal calprotectin provide a useful tool for interpreting the probabilities of presenting endoscopic activity or mucosal healing, and are valuable in the specific clinical context.enAdolescentAdultAgedBiomarkersCrohn DiseaseEndoscopy, GastrointestinalFecesFemaleHumansLeukocyte L1 Antigen ComplexMaleMiddle AgedPredictive Value of TestsPyruvate KinaseReference ValuesYoung Adultresearch article28071062open access10.17235/reed.2017.4542/2016https://doi.org/10.17235/reed.2017.4542/2016