Barrecheguren, MiriamKostikas, KonstantinosMezzi, KarenShen, StevenAlcazar, BernardinoSoler-Cataluña, Juan JoséMiravitlles, MarcWedzicha, Jadwiga A2025-01-072025-01-072020-02-10https://hdl.handle.net/10668/25848The concept of chronic obstructive pulmonary disease (COPD) control has been proposed to guide treatment decisions in COPD. In this study, we aimed to validate the prospective value of this concept in the SPARK study population. Control was assessed based on COPD stability and impact. Patients with low impact and stability during weeks 1-12 were classified as controlled, and exacerbations were measured during a 52-week follow-up. Of the 2044 patients included a majority were non-controlled (80%), frequently due to high impact. During the follow-up, the rate of moderate/severe exacerbations was significantly lower in controlled patients (rate ratio, 0.56, 95% CI 0.48 to 0.65 penCOPD ExacerbationsAgedBronchodilator AgentsDisease ProgressionDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleDrug Therapy, CombinationFemaleGlycopyrrolateHumansIndansMaleMiddle AgedProspective StudiesPulmonary Disease, Chronic ObstructiveQuinolonesReproducibility of ResultsRespiratory Function TestsRisk AssessmentSeverity of Illness IndexTiotropium BromideTreatment Outcomeresearch article32041741open access10.1136/thoraxjnl-2018-2127521468-3296https://thorax.bmj.com/content/thoraxjnl/75/4/351.full.pdf