de Rojas, ItziarHernandez, IsabelMontrreal, LauraQuintela, InesCalero, MiguelRoyo, Jose LuisHuerto Vilas, RaquelGonzalez-Perez, AntonioFranco-Macias, EmilioMacias, JuanMenendez-Gonzalez, ManuelFrank-Garcia, AnaDiez-Fairen, MonicaLage, CarmenGarcia-Madrona, SebastianAguilera, NuriaGarcia-Gonzalez, PabloPuerta, RaquelSotolongo-Grau, OscarAlonso-Lana, SilviaRabano, AlbertoArias Pastor, AlfonsoPastor, Ana BelenCorma-Gomez, AnaisMartin Montes, AngelMartinez Rodriguez, CarmenBuiza-Rueda, DoloresPerinan, Maria TeresaRodriguez-Rodriguez, EloyAlvarez, IgnacioAllende, Irene RosasPineda, Juan A. A.Bernal Sanchez-Arjona, MariaFernandez-Fuertes, MartaMendoza, Silviadel Ser, TeodoroGarcia-Ribas, GuillermoSanchez-Juan, PascualPastor, PauBullido, Maria J.Alvarez, VictoriaReal, Luis M. M.Mir, PabloPinol-Ripoll, GerardGarcia-Alberca, Jose MariaMedina, MiguelOrellana, AdelinaButler, Chris R. R.Marquie, MartaSaez, Maria EugeniaCarracedo, AngelTarraga, LluisBoada, MerceRuiz, Agustin2025-01-072025-01-072021-12-01https://hdl.handle.net/10668/27289Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/SARS-CoV-2COVID-19GWASGR@ACEDEGESCOdementiaAPOEApolipoprotein-eGenotypeDiseaseresearch article34945790open access10.3390/jpm111213182075-4426https://www.mdpi.com/2075-4426/11/12/1318/pdf?version=1638872094747106400001