Lope, VirginiaGuerrero-Zotano, ÁngelCasas, AnaBaena-Cañada, José ManuelBermejo, BegoñaPérez-Gómez, BeatrizCriado-Navarro, InmaculadaAntolín, SilviaSánchez-Rovira, PedroRamos-Vázquez, ManuelAntón, AntonioCastelló, AdelaGarcía-Saénz, José ÁngelMuñoz, Montserratde Juan, AnaAndrés, RaquelLlombart-Cussac, AntonioHernando, BlancaFranquesa, Rosa MaríaCaballero, RosaliaPriego-Capote, FelicianoMartín, MiguelPollán, Marina2022-08-092022-08-092020-10-14Lope V, Guerrero-Zotano Á, Casas A, Baena-Cañada JM, Bermejo B, Pérez-Gómez B, et al. Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype. Nutrients. 2020 Oct 14;12(10):3132http://hdl.handle.net/10668/3895This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30-0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49-0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48-0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20-2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12-2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14-2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45-2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Breast neoplasmBreast cancer subtypesDesaturation indicesFatsEpiGEICAMNeoplasias de la mamaGrasasEstudios de casos y controlesFosfolípidosÁcidos grasosMedical Subject Headings::Persons::Persons::Age Groups::AdultMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, PharmacologicalMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast NeoplasmsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control StudiesMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty AcidsMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding BehaviorMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Persons::Persons::Age Groups::Adult::Middle AgedMedical Subject Headings::Chemicals and Drugs::Lipids::PhospholipidsMedical Subject Headings::Phenomena and Processes::Mathematical Concepts::Probability::RiskMedical Subject Headings::Geographical Locations::Geographic Locations::Europe::SpainMedical Subject Headings::Information Science::Information Science::Data Collection::Questionnairesresearch article33066483open access10.3390/nu121031322072-6643PMC7602197