Sardjoe Mishre, Aashley S DMartinez-Tellez, BorjaAcosta, Francisco MSanchez-Delgado, GuillermoStraat, Maaike EWebb, Andrew GKan, Hermien ERensen, Patrick C NRuiz, Jonatan R2023-05-032023-05-032022-06-03Sardjoe Mishre ASD, Martinez-Tellez B, Acosta FM, Sanchez-Delgado G, Straat ME, Webb AG, et al. Association of shivering threshold time with body composition and brown adipose tissue in young adults. J Therm Biol. 2022 Aug;108:103277.0306-4565http://hdl.handle.net/10668/22341Brown adipose tissue (BAT) increases metabolic heat production in response to cold exposure. Body size and composition are involved in the human cold response, yet the influence of BAT herein have not fully been explored. Here, we aimed to study the association of the cold-induced shivering threshold time with body composition, BAT, the perception of shivering and skin temperature in young adults. 110 young healthy adults (81 females; age = 21.7 ± 2.1 years, BMI = 24.2 ± 4.3 kg/m2) underwent 2 h of individualized cooling, followed by the quantification of BAT using a18F-fluorodeoxyglucose ([18F]FDG) positron emission tomography-computed tomography (PET-CT) scan. Body mass index (BMI), lean mass, fat mass and body surface area (BSA) were also measured. Shivering threshold time was defined as the time until shivering occurred using an individualized cooling protocol. The shivering threshold time was on average 116.1 min for males and 125.8 min for females, and was positively associated to BMI (β = 3.106; R2 = 0.141; p = 0.001), lean mass (β = 2.295; R2 = 0.128; p = 0.001) and fat mass (β = 1.492; R2 = 0.121; p = 0.001) in females, but not in males (all p ≥ 0.409). The shivering threshold time was positively associated with BSA in males (p = 0.047) and females (p = 0.001), but it was not associated with BAT volume or [18F]FDG uptake nor with the perception of shivering and skin temperature perception in both sexes. The shivering threshold time is positively associated with whole-body adiposity and lean mass in females, but not in males. The shivering threshold time was positively associated with BSA, but no association was observed with BAT nor with the perception of shivering or skin temperature. Future research should consider the influence of body composition when applying cooling protocols among individuals with different phenotypical features.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Cold perceptionShivering timeThermogenesisbrown fatAdipose Tissue, BrownAdultBody CompositionCold TemperatureFemaleFluorodeoxyglucose F18HumansMalePositron Emission Tomography Computed TomographyShiveringYoung Adultresearch article36031206open accessAdultoComposición corporalFemeninoFluorodesoxiglucosa F18FríoHumanosTejido adiposo pardoTiritonaTomografía computarizada por tomografía de emisión de positrones10.1016/j.jtherbio.2022.103277https://doi.org/10.1016/j.jtherbio.2022.103277