Méndez-Echevarría, AnaSainz, Talíade Felipe, BeatrizAlcolea, SoniaOlbrich, PeterGoycochea-Valdivia, Walter AEscosa-García, LuisCobo, LorenaCalvo, CristinaNeth, Olaf2023-02-092023-02-092021http://hdl.handle.net/10668/17187Data on SARS-CoV-2 transmission among children living with healthcare workers (HCWs) are scarce. A cross-sectional study was performed at a tertiary Hospital in Madrid, including children of HCW who suffered from SARS-CoV-2 infection between March and May 2020. Children underwent enzyme-linked immunosorbent serological study for detecting SARS-CoV-2 antibodies: VIRCELL IgG assay. One hundred thirteen children from 69 HCWs with confirmed SARS-CoV-2 infection were recruited: 47 children had positive IgG (41.6%). Children secondary attack rate was 43.7% (25% if both parents have had asymptomatic infection; 39.5% if one parent was symptomatic; and 47% when both parents had symptoms). Having a positive sibling was associated with a positive IgG result (odds ratio = 12.2; 95% confidence interval: 4.4-33.7, P We observed a very high SARS-CoV-2 transmission in children of HCW during the first pandemic wave, especially when both parents were symptomatic. Having a positive sibling was associated with seroconversion, supporting the important role of family clusters in the transmission of SARS-CoV-2.enAdolescentAntibodies, ViralAsymptomatic InfectionsCOVID-19ChildChild, PreschoolCross-Sectional StudiesDisease Transmission, InfectiousFamilyFemaleHealth PersonnelHumansImmunoglobulin GInfectious Disease Transmission, Patient-to-ProfessionalMalePandemicsSARS-CoV-2SeroconversionSpainTertiary Care CentersHigh Rates of SARS-CoV-2 Family Transmission in Children of Healthcare Workers During the First Pandemic Wave in Madrid, Spain: Serologic Study.research article33591078open access10.1097/INF.00000000000030881532-0987https://journals.lww.com/pidj/Fulltext/2021/05000/High_Rates_of_SARS_CoV_2_Family_Transmission_in.17.aspx