Murphy, NeilNorat, TeresaFerrari, PietroJenab, MazdaBueno-de-Mesquita, BasSkeie, GuriDahm, Christina COvervad, KimOlsen, AnjaTjønneland, AnneClavel-Chapelon, FrançoiseBoutron-Ruault, Marie ChristineRacine, AntoineKaaks, RudolfTeucher, BirgitBoeing, HeinerBergmann, Manuela MTrichopoulou, AntoniaTrichopoulos, DimitriosLagiou, PagonaPalli, DomenicoPala, ValeriaPanico, SalvatoreTumino, RosarioVineis, PaoloSiersema, Petervan Duijnhoven, FranzelPeeters, Petra H MHjartaker, AnetteEngeset, DagrunGonzález, Carlos ASanchez-Perez, Maria-JoseDorronsoro, MirenNavarro, CarmenArdanaz, EvaQuirós, José RSonestedt, EmilyEricson, UlrikaNilsson, LenaPalmqvist, RichardKhaw, Kay-TeeWareham, NickKey, Timothy JCrowe, Francesca LFedirko, VeronikaWark, Petra AChuang, Shu-ChunRiboli, Elio2013-02-142013-02-142012-06-22Murphy N, Norat T, Ferrari P, Jenab M, Bueno-de-Mesquita B, Skeie G, et al. Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). PLoS ONE 2012; 7(6):e39361http://hdl.handle.net/10668/773PubMed - in process.BACKGROUND Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location. METHODOLOGY/PRINCIPAL FINDINGS After a mean follow-up of 11.0 years, 4,517 incident cases of colorectal cancer were documented. Total, cereal, fruit, and vegetable fibre intakes were estimated from dietary questionnaires at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. After multivariable adjustments, total dietary fibre was inversely associated with colorectal cancer (HR per 10 g/day increase in fibre 0.87, 95% CI: 0.79-0.96). Similar linear associations were observed for colon and rectal cancers. The association between total dietary fibre and risk of colorectal cancer risk did not differ by age, sex, or anthropometric, lifestyle, and dietary variables. Fibre from cereals and fibre from fruit and vegetables were similarly associated with colon cancer; but for rectal cancer, the inverse association was only evident for fibre from cereals. CONCLUSIONS/SIGNIFICANCE Our results strengthen the evidence for the role of high dietary fibre intake in colorectal cancer prevention.enColorectal NeoplasmsDietary FiberNeoplasias ColorrectalesFibras en la DietaMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal NeoplasmsMedical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Dietary FiberMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studiesresearch article22761771open access10.1371/journal.pone.00393611932-6203PMC3382210