García-Caballero, MelissaQuesada, Ana RMedina, Miguel AMarí-Beffa, Manuel2023-01-252023-01-252017-10-31http://hdl.handle.net/10668/11744Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a higher-throughput screening capability compared with other available animal models. Externally growing, transparent embryos, displaying well-defined blood and lymphatic vessels, allow the inexpensive, rapid, and automatable evaluation of drug candidates that are able to inhibit neovascularisation. Here, we briefly review zebrafish as a model for the screening of anti(lymph)angiogenic drugs, with emphasis on the advantages and limitations of the different zebrafish-based in vivo assays.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Angiogenesis InhibitorsAnimalsDrug Evaluation, PreclinicalHumansModels, AnimalNeovascularization, PathologicZebrafishresearch article29081356open access10.1016/j.drudis.2017.10.0181878-5832https://riuma.uma.es/xmlui/bitstream/10630/16662/1/2018-02-zebrafish%20rev-DDT.pdf