Barnestein-Fonseca, PilarLeiva-Fernández, JoséVidal-España, FranciscaGarcía-Ruiz, AntonioPrados-Torres, DanielLeiva-Fernández, Francisca2013-10-312013-10-312011-02-14Barnestein-Fonseca P, Leiva-Fernández J, Vidal-España F, García-Ruiz A, Prados-Torres D, Leiva-Fernández F. Efficacy and safety of a multifactor intervention to improve therapeutic adherence in patients with chronic obstructive pulmonary disease (COPD): protocol for the ICEPOC study. Trials. 2011; 12:40http://hdl.handle.net/10668/1367Journal Article; Randomized Controlled Trial (Current Controlled Trials ISRCTN18841601);Low therapeutic adherence to medication is very common. Clinical effectiveness is related to dose rate and route of administration and so poor therapeutic adherence can reduce the clinical benefit of treatment. The therapeutic adherence of patients with chronic obstructive pulmonary disease (COPD) is extremely poor according to most studies. The research about COPD adherence has mainly focussed on quantifying its effect, and few studies have researched factors that affect non-adherence. Our study will evaluate the effectiveness of a multifactor intervention to improve the therapeutic adherence of COPD patients.enBroncodilatadoresConductas saludablesCumplimiento de la medicaciónNebulizadores y vaporizadoresEducación del paciente como asuntoEnfermedad Pulmonar Obstructiva CrónicaResultado del tratamientoAdministración por inhalaciónMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Respiratory System Agents::Anti-Asthmatic Agents::Bronchodilator AgentsMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior MechanismsMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Delivery of Health Care::Attitude to Health::Health Knowledge, Attitudes, PracticeMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Delivery of Health Care::Attitude to Health::Patient Acceptance of Health Care::Patient Compliance::Medication AdherenceMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Nebulizers and VaporizersMedical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Services::Community Health ServicesMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Reinforcement (Psychology)Medical Subject Headings::Geographicals::Geographic Locations::Europe::SpainMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment OutcomeMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Administration, Inhalationresearch article21320300open access10.1186/1745-6215-12-401745-6215PMC3049740