Barrios, RocíoBravo, ManuelGil-Montoya, Jose AntonioMartínez-Lara, IldefonsoGarcía-Medina, BlasTsakos, Georgios2015-12-222015-12-222015-01-23Barrios R, Bravo M, Gil-Montoya JA, Martínez-Lara I, García-Medina B, Tsakos G. Oral and general health-related quality of life in patients treated for oral cancer compared to control group. Health Qual Life Outcomes. 2015; 13:9http://hdl.handle.net/10668/2115Journal Article; Research Support, Non-U.S. Gov't;BACKGROUND Health-related quality of life (HRQoL) is gaining importance as a valuable outcome measure in oral cancer area. The aim of this study was to assess the general and oral HRQoL of oral and oropharyngeal cancer patients 6 or more months after treatment and compare them with a population free from this disease. METHODS A cross-sectional study was carried out with patients treated for oral cancer at least 6 months post-treatment and a gender and age group matched control group. HRQoL was measured with the 12-Item Short Form Health Survey (SF-12); oral HRQoL (OHRQoL) was evaluated using the Oral Health Impact Profile (OHIP-14) and the Oral Impacts on Daily Performances (OIDP). Multivariable regression models assessed the association between the outcomes (SF-12, OHIP-14 and OIDP) and the exposure (patients versus controls), adjusting for sex, age, social class, functional tooth units and presence of illness. RESULTS For patients (n = 142) and controls (n = 142), 64.1% were males. The mean age was 65.2 (standard deviation (sd): 12.9) years in patients and 67.5 (sd: 13.7) years in controls. Patients had worse SF-12 Physical Component Summary scores than controls even in fully the adjusted model [β-coefficient = -0.11 (95% CI: -5.12-(-0.16)]. The differences in SF-12 Mental Component Summary were not statistically significant. Regarding OHRQoL patients had 11.63 (95% CI: 6.77-20.01) higher odds for the OHIP-14 and 21.26 (95% CI: 11.54-39.13) higher odds for OIDP of being in a worse category of OHRQoL compared to controls in the fully adjusted model. CONCLUSION At least 6 months after treatment, oral cancer patients had worse OHRQoL, worse physical HRQoL and similar psychological HRQoL than the general population.enOral cancerQuality of lifeSF-12OHIPOIDPNeoplasias de la BocaCalidad de vidaCuestionariosGrupos controlHumanosMasculinoSalud bucalNeoplasias orofaríngeasEvaluación del desenlace (asistencia sanitaria)Clase socialMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Mouth NeoplasmsMedical Subject Headings::Disciplines and Occupations::Social Sciences::Quality of LifeMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Otorhinolaryngologic Neoplasms::Pharyngeal Neoplasms::Oropharyngeal NeoplasmsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::QuestionnairesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Control GroupsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional StudiesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health SurveysMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Health Care::Population Characteristics::Health::Oral HealthMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Otorhinolaryngologic Neoplasms::Pharyngeal Neoplasms::Oropharyngeal NeoplasmsMedical Subject Headings::Health Care::Health Services Administration::Quality of Health Care::Outcome and Process Assessment (Health Care)::Outcome Assessment (Health Care)Medical Subject Headings::Health Care::Population Characteristics::Socioeconomic Factors::Social Classresearch article25613348open access10.1186/s12955-014-0201-51477-7525PMC4311475