Buyck, Pieter-JanZuurbier, Susanna MGarcia-Esperon, CarlosBarboza, Miguel ACosta, PaoloEscudero, IreneRenard, DimitriLemmens, RobinHinteregger, NicoleFazekas, FranzConde, Jordi JimenezGiralt-Steinhauer, EvaHiltunen, SiniArauz, AntonioPezzini, AlessandroMontaner, JoanPutaala, JukkaWeimar, ChristianChurilov, LeonidGattringer, ThomasAsadi, HamedTatlisumak, TurgutCoutinho, Jonathan MDemaerel, PhilippeThijs, Vincent2023-01-252023-01-252019-01-18http://hdl.handle.net/10668/13433To assess the added diagnostic value of semiquantitative imaging markers on noncontrast CT scans in cerebral venous thrombosis (CVT). In a retrospective, multicenter, blinded, case-control study of patients with recent onset ( We enrolled 285 patients with CVT and 303 controls from 10 international centers. Sensitivity of visual impression of thrombosis ranged from 41% to 73% and specificity ranged from 97% to 100%. Attenuation measurement had an area under the curve (AUC) of 0.78 (95% confidence interval [CI] 0.74-0.81). After adjustment for hematocrit, the AUC remained 0.78 (95% CI 0.74-0.81). The analysis of attenuation ratios of affected vs unaffected sinuses had AUC of 0.83 (95% CI 0.8-0.86). Adding this imaging marker significantly improved discrimination, but sensitivity when tolerating a false-positive rate of 20% was not higher than 76% (95% CI 0.70-0.81). Semiquantitative analysis of attenuation values for diagnosis of CVT increased sensitivity but still failed to identify 1 out of 4 CVT. This study provides Class II evidence that visual analysis of plain CT with or without attenuation measurements has high specificity but only moderate sensitivity for CVT.enAdultArea Under CurveCase-Control StudiesCerebral AngiographyCerebral VeinsComputed Tomography AngiographyFemaleHumansIntracranial ThrombosisMagnetic Resonance AngiographyMaleMiddle AgedPhlebographyRetrospective StudiesSensitivity and SpecificitySinus Thrombosis, IntracranialTomography, X-Ray ComputedVenous Thrombosisresearch article30659138open access10.1212/WNL.00000000000069591526-632Xhttps://lirias.kuleuven.be/bitstream/123456789/634973/2/e841.full.pdf