Schott, Jonathan MCrutch, Sebastian JCarrasquillo, Minerva MUphill, JamesShakespeare, Tim JRyan, Natalie SYong, Keir XLehmann, ManjaErtekin-Taner, NiluferGraff-Radford, Neill RBoeve, Bradley FMurray, Melissa EKhan, Qurat Ul AinPetersen, Ronald CDickson, Dennis WKnopman, David SRabinovici, Gil DMiller, Bruce LGonzález, Aida SuárezGil-Néciga, EulogioSnowden, Julie SHarris, JennyPickering-Brown, Stuart MLouwersheimer, Evavan der Flier, Wiesje MScheltens, PhilipPijnenburg, Yolande AGalasko, DouglasSarazin, MarieDubois, BrunoMagnin, EloiGalimberti, DanielaScarpini, ElioCappa, Stefano FHodges, John RHalliday, Glenda MBartley, LaurenCarrillo, Maria CBras, Jose THardy, JohnRossor, Martin NCollinge, JohnFox, Nick CMead, Simon2023-01-252023-01-252016-03-15http://hdl.handle.net/10668/9929The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain. We genotyped 302 PCA patients from 11 centers, calculated risk at 24 loci for AD/DLB and performed an exploratory genome-wide association study. We confirm that variation in/near APOE/TOMM40 (P = 6 × 10(-14)) alters PCA risk, but with smaller effect than for typical AD (PCA: odds ratio [OR] = 2.03, typical AD: OR = 2.83, P = .0007). We found evidence for risk in/near CR1 (P = 7 × 10(-4)), ABCA7 (P = .02) and BIN1 (P = .04). ORs at variants near INPP5D and NME8 did not overlap between PCA and typical AD. Exploratory genome-wide association studies confirmed APOE and identified three novel loci: rs76854344 near CNTNAP5 (P = 8 × 10(-10) OR = 1.9 [1.5-2.3]); rs72907046 near FAM46A (P = 1 × 10(-9) OR = 3.2 [2.1-4.9]); and rs2525776 near SEMA3C (P = 1 × 10(-8), OR = 3.3 [2.1-5.1]). We provide evidence for genetic risk factors specifically related to PCA. We identify three candidate loci that, if replicated, may provide insights into selective vulnerability and phenotypic diversity in AD.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/APOEAlzheimer's diseaseGWASGeneticsPosterior cortical atrophySelective vulnerabilityAge FactorsAgedAlzheimer DiseaseApolipoproteins EAtrophyCell Adhesion Molecules, NeuronalCerebral CortexFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleMembrane Transport ProteinsMiddle AgedMitochondrial Precursor Protein Import Complex ProteinsPolymorphism, Single NucleotidePolynucleotide AdenylyltransferaseProteinsReceptors, Complement 3bRisk FactorsSemaphorinsresearch article26993346open access10.1016/j.jalz.2016.01.0101552-5279PMC4982482https://doi.org/10.1016/j.jalz.2016.01.010https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982482/pdf