de Oliveira, JadeKucharska, EwaGarcez, Michelle LimaRodrigues, Matheus ScarpattoQuevedo, JoãoMoreno-Gonzalez, InesBudni, Josiane2022-05-052022-05-052021-09-28de Oliveira J, Kucharska E, Garcez ML, Rodrigues MS, Quevedo J, Moreno-Gonzalez I, et al. Inflammatory Cascade in Alzheimer's Disease Pathogenesis: A Review of Experimental Findings. Cells. 2021 Sep 28;10(10):2581http://hdl.handle.net/10668/3613Alzheimer's disease (AD) is the leading cause of dementia worldwide. Most AD patients develop the disease in late life, named late onset AD (LOAD). Currently, the most recognized explanation for AD pathology is the amyloid cascade hypothesis. It is assumed that amyloid beta (Aβ) aggregation and deposition are critical pathogenic processes in AD, leading to the formation of amyloid plaques, as well as neurofibrillary tangles, neuronal cell death, synaptic degeneration, and dementia. In LOAD, the causes of Aβ accumulation and neuronal loss are not completely clear. Importantly, the blood-brain barrier (BBB) disruption seems to present an essential role in the induction of neuroinflammation and consequent AD development. In addition, we propose that the systemic inflammation triggered by conditions like metabolic diseases or infections are causative factors of BBB disruption, coexistent inflammatory cascade and, ultimately, the neurodegeneration observed in AD. In this regard, the use of anti-inflammatory molecules could be an interesting strategy to treat, delay or even halt AD onset and progression. Herein, we review the inflammatory cascade and underlying mechanisms involved in AD pathogenesis and revise the anti-inflammatory effects of compounds as emerging therapeutic drugs against AD.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Alzheimer’s diseaseNeurodegenerative diseaseDementiaNeuroinflammationInflammatory cascadeSystemic inflammationBBB disruptionAnti-inflammatory effectsTherapyEnfermedad de AlzheimerEnfermedades neurodegenerativasDemenciaTerapéuticaSíndrome de respuesta inflamatoria sistémicaMedical Subject Headings::Persons::Persons::Age Groups::Adult::AgedMedical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Dementia::Alzheimer DiseaseMedical Subject Headings::Organisms::Eukaryota::AnimalsMedical Subject Headings::Diseases::Animal Diseases::Disease Models, AnimalMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell DeathMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antirheumatic AgentsMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation::Systemic Inflammatory Response Syndromereview article34685563Acceso abierto10.3390/cells101025812073-4409PMC8533897