No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial.

Martinez-Tellez, BorjaSanchez-Delgado, GuillermoAcosta, Francisco MAlcantara, Juan M AAmaro-Gahete, Francisco JMartinez-Avila, Wendy DMerchan-Ramirez, ElisaMuñoz-Hernandez, VictoriaOsuna-Prieto, Francisco JJurado-Fasoli, LucasXu, HuiwenOrtiz-Alvarez, LourdesArias-Tellez, Maria JMendez-Gutierrez, AndreaLabayen, IdoiaOrtega, Francisco BSchönke, MilenaRensen, Patrick C NAguilera, Concepcion MLlamas-Elvira, Jose MGil, AngelRuiz, Jonatan R2023-05-032023-05-032022-08-02Martinez-Tellez B, Sanchez-Delgado G, Acosta FM, Alcantara JMA, Amaro-Gahete FJ, Martinez-Avila WD, et al. No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial. Nat Commun. 2022 Sep 12;13(1):5259.http://hdl.handle.net/10668/19544Exercise modulates both brown adipose tissue (BAT) metabolism and white adipose tissue (WAT) browning in murine models. Whether this is true in humans, however, has remained unknown. An unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129) was therefore conducted to study the effects of a 24-week supervised exercise intervention, combining endurance and resistance training, on BAT volume and activity (primary outcome). The study was carried out in the Sport and Health University Research Institute and the Virgen de las Nieves University Hospital of the University of Granada (Spain). One hundred and forty-five young sedentary adults were assigned to either (i) a control group (no exercise, n = 54), (ii) a moderate intensity exercise group (MOD-EX, n = 48), or (iii) a vigorous intensity exercise group (VIG-EX n = 43) by unrestricted randomization. No relevant adverse events were recorded. 97 participants (34 men, 63 women) were included in the final analysis (Control; n = 35, MOD-EX; n = 31, and VIG-EX; n = 31). We observed no changes in BAT volume (Δ Control: -22.2 ± 52.6 ml; Δ MOD-EX: -15.5 ± 62.1 ml, Δ VIG-EX: -6.8 ± 66.4 ml; P = 0.771) or 18F-fluorodeoxyglucose uptake (SUVpeak Δ Control: -2.6 ± 3.1 ml; Δ MOD-EX: -1.2 ± 4.8, Δ VIG-EX: -2.2 ± 5.1; p = 0.476) in either the control or the exercise groups. Thus, we did not find any evidence of an exercise-induced change on BAT volume or activity in young sedentary adults.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Resistance TrainingControl GroupsDisease Models, AnimalRandom AllocationExercise TherapyControl GroupsAdipose Tissue, BrownAdultAnimalsFemaleFluorodeoxyglucose F18HumansMaleMiceSpainNo evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial.research article36097264open accessFluorodesoxiglucosa F18AdultoAnimalesEspañaFemeninoHumanosMasculinoRatonesTejido adiposo pardo10.1038/s41467-022-32502-x2041-1723PMC9467993https://www.nature.com/articles/s41467-022-32502-x.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467993/pdf