Frantzi, MariaGomez Gomez, EnriqueBlanca Pedregosa, AnaValero Rosa, JoseLatosinska, AgnieszkaCulig, ZoranMerseburger, Axel SLuque, Raul MRequena Tapia, Maria JoseMischak, HaraldCarrasco Valiente, Julia2023-01-252023-01-252019-04-16http://hdl.handle.net/10668/13969Prostate cancer progresses slowly when present in low risk forms but can be lethal when it progresses to metastatic disease. A non-invasive test that can detect significant prostate cancer is needed to guide patient management. Capillary electrophoresis/mass spectrometry has been employed to identify urinary peptides that may accurately detect significant prostate cancer. Urine samples from 823 patients with PSA ( Independent validation of the 19-biomarker model in 280 patients resulted in a 90% sensitivity and 59% specificity, with an AUC of 0.81, outperforming PSA (AUC = 0.58) and the ERSPC-3/4 risk calculator (AUC = 0.69) in the validation set. This multi-parametric model holds promise to improve the current diagnosis of significant prostate cancer. This test as a guide to biopsy could help to decrease the number of biopsies and guide intervention. Nevertheless, further prospective validation in an external clinical cohort is required to assess the exact performance characteristics.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AlgorithmsBiomarkers, tumorCase-control studiesElectrophoresis, capillaryAgedHumansImage-guided biopsyMaleMass spectrometryMiddle agedProstatic neoplasmsSupport vector machineUltrasonography, interventionalresearch article31092909open accessBiopsia guiada por imagenEspectrometría de masasMáquina de vectores de soporteNeoplasias de la próstataUltrasonografía Intervencional10.1038/s41416-019-0472-z1532-1827PMC6738044https://www.nature.com/articles/s41416-019-0472-z.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738044/pdf