Frias, MarioMoyano, Jose MRivero-Juarez, AntonioLuna, Jose MCamacho, AngelaFardoun, Habib MMachuca, IsabelAl-Twijri, MohamedRivero, AntonioVentura, Sebastian2023-02-092023-02-092020-12-17Frias M, Moyano JM, Rivero-Juarez A, Luna JM, Camacho Á, Fardoun HM, et al. Classification Accuracy of Hepatitis C Virus Infection Outcome: Data Mining Approach. J Med Internet Res. 2021 Feb 24;23(2):e18766http://hdl.handle.net/10668/17227The dataset from genes used to predict hepatitis C virus outcome was evaluated in a previous study using a conventional statistical methodology. The aim of this study was to reanalyze this same dataset using the data mining approach in order to find models that improve the classification accuracy of the genes studied. We built predictive models using different subsets of factors, selected according to their importance in predicting patient classification. We then evaluated each independent model and also a combination of them, leading to a better predictive model. Our data mining approach identified genetic patterns that escaped detection using conventional statistics. More specifically, the partial decision trees and ensemble models increased the classification accuracy of hepatitis C virus outcome compared with conventional methods. Data mining can be used more extensively in biomedicine, facilitating knowledge building and management of human diseases.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/HIV/HCVPARTClassification accuracyData miningEnsembleAlgorithmsData miningHepacivirusHumansresearch article33624609open accessAlgoritmosHepacivirusHumanosMinería de datos10.2196/187661438-8871PMC7946589https://www.jmir.org/2021/2/e18766/PDFhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7946589/pdf