Mycobacterium tuberculosis Acquires Limited Genetic Diversity in Prolonged Infections, Reactivations and Transmissions Involving Multiple Hosts

Herranz, MartaPole, IlvaOzere, IvetaChiner-Oms, AlvaroMartinez-Lirola, MiguelPerez-Garcia, FelipeGijon, PalomaRuiz Serrano, Maria JesusClotet Romero, LauraCuevas, OscarComas, InakiBouza, EmilioPerez-Lago, LauraGarcia-de-Viedma, Dario2023-02-122023-02-122018-01-191664-302Xhttp://hdl.handle.net/10668/19225Background: Mycobacterium tuberculosis (MTB) has limited ability to acquire variability. Analysis of its microevolution might help us to evaluate the pathways followed to acquire greater infective success. Whole-genome sequencing (WGS) in the analysis of the transmission of MTB has elucidated the magnitude of variability in MTB. Analysis of transmission currently depends on the identification of clusters, according to the threshold of variability (enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/tuberculosisvariabilitywhole genome sequencingSNPsmicroevolutionClonal variantsMicroevolutionOutbreaksStrainAfricaMycobacterium tuberculosis Acquires Limited Genetic Diversity in Prolonged Infections, Reactivations and Transmissions Involving Multiple Hostsresearch articleopen access10.3389/fmicb.2017.02661https://www.frontiersin.org/articles/10.3389/fmicb.2017.02661/pdf422951200001