Ferrer-Quintero, MFernandez, DLopez-Carrilero, RBirules, IBarajas, ALorente-Rovira, ELuengo, ADiaz-Cutraro, LVerdaguer, MGarcia-Mieres, HGutierrez-Zotes, AGrasa, EPousa, EHuerta-Ramos, EPelaez, TBarrigon, M LGomez-Benito, JGonzalez-Higueras, FRuiz-Delgado, ICid, JMoritz, SSevilla-Llewellyn-Jones, JOchoa, S2023-05-032023-05-032022-07-08Ferrer-Quintero M, Fernández D, López-Carrilero R, Birulés I, Barajas A, Lorente-Rovira E, et al. Males and females with first episode psychosis present distinct profiles of social cognition and metacognition. Eur Arch Psychiatry Clin Neurosci. 2022 Oct;272(7):1169-1181http://hdl.handle.net/10668/19997Deficits in social cognition and metacognition impact the course of psychosis. Sex differences in social cognition and metacognition could explain heterogeneity in psychosis. 174 (58 females) patients with first-episode psychosis completed a clinical, neuropsychological, social cognitive, and metacognitive assessment. Subsequent latent profile analysis split by sex yielded two clusters common to both sexes (a Homogeneous group, 53% and 79.3%, and an Indecisive group, 18.3% and 8.6% of males and females, respectively), a specific male profile characterized by presenting jumping to conclusions (28.7%) and a specific female profile characterized by cognitive biases (12.1%). Males and females in the homogeneous profile seem to have a more benign course of illness. Males with jumping to conclusions had more clinical symptoms and more neuropsychological deficits. Females with cognitive biases were younger and had lower self-esteem. These results suggest that males and females may benefit from specific targeted treatment and highlights the need to consider sex when planning interventions.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/MetacognitionProfilesPsychosisSchizophreniaSex differencesSocial cognitionÁrea de Gestión Sanitaria Sur de GranadaCognitionCognition DisordersFemaleHumansMaleMetacognitionPsychotic Disordersresearch article35802165open accessTrastornos psicóticosMetacogniciónCognición socialCaracteres sexuales10.1007/s00406-022-01438-01433-8491PMC9508015https://link.springer.com/content/pdf/10.1007/s00406-022-01438-0.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508015/pdf