Boughanem, HatimMartin-Nuñez, Gracia MaríaTorres, EsperanzaArranz-Salas, IsabelAlcaide, JuliaMorcillo, SonsolesTinahones, Francisco JCrujeiras, Ana BMacias-Gonzalez, Manuel2025-01-072025-01-072020-11-112075-4426https://hdl.handle.net/10668/24558Recent studies suggest that long-interspersed nucleotide element-1 (LINE-1) hypomethylation is commonly found in colorectal cancer (CRC), and is associated with worse prognosis. However, the utility of LINE-1 methylation on the prognosis of CRC is still controversial, and may be due to the fact that some clinical and pathological features may affect LINE-1 methylation. Thus, the aim of this study was to assess the prognostic value of tumor LINE-1 methylation in CRC, through their association with the CRC clinical and pathological characteristics. Survival of sixty-seven CRC patients was evaluated according to the median of tumor LINE-1 methylation, as well as pathological and oncological variables. We also studied the association between LINE-1 methylation and pathological features, and finally, we assessed the overall and disease-free survival of LINE1 methylation, stratified by neoadjuvant treatment and further checked by multivariate Cox regression to assess the statistical interactions. LINE-1 was hypomethylated in the CRC tumor with respect to the tumor adjacent-free area (penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/LINE-1colorectal cancermethylationsurvivaltumorresearch article33187096open access10.3390/jpm10040219PMC7712476https://www.mdpi.com/2075-4426/10/4/219/pdf?version=1605076276https://pmc.ncbi.nlm.nih.gov/articles/PMC7712476/pdf