López-Mejías, RaquelGenre, FernandaRemuzgo-Martínez, SaraGonzález-Juanatey, CarlosRobustillo-Villarino, MontserratLlorca, JavierCorrales, AlfonsoVicente, EstherMiranda-Filloy, José AMagro, CésarTejera-Segura, BeatrizRamírez Huaranga, Marco APina, TrinitarioBlanco, RicardoAlegre-Sancho, Juan JRaya, EnriqueMijares, VerónicaUbilla, BegoñaMínguez Sánchez, María DGómez-Vaquero, CarmenBalsa, AlejandroPascual-Salcedo, DoraLópez-Longo, Francisco JCarreira, PatriciaGonzález-Álvaro, IsidoroRodríguez-Rodríguez, LuisFernández-Gutiérrez, BenjamínFerraz-Amaro, IvánCastañeda, SantosMartín, JavierGonzález-Gay, Miguel A2016-10-192016-10-192016-08-18López-Mejías R, Genre F, Remuzgo-Martínez S, González-Juanatey C, Robustillo-Villarino M, Llorca J, et al. Influence of elevated-CRP level-related polymorphisms in non-rheumatic Caucasians on the risk of subclinical atherosclerosis and cardiovascular disease in rheumatoid arthritis. Sci Rep. 2016; 6:31979http://hdl.handle.net/10668/2474Journal Article;Association between elevated C-reactive protein (CRP) serum levels and subclinical atherosclerosis and cardiovascular (CV) events was described in rheumatoid arthritis (RA). CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 exert an influence on elevated CRP serum levels in non-rheumatic Caucasians. Consequently, we evaluated the potential role of these genes in the development of CV events and subclinical atherosclerosis in RA patients. Three tag CRP polymorphisms and HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were genotyped in 2,313 Spanish patients by TaqMan. Subclinical atherosclerosis was determined in 1,298 of them by carotid ultrasonography (by assessment of carotid intima-media thickness-cIMT-and presence/absence of carotid plaques). CRP serum levels at diagnosis and at the time of carotid ultrasonography were measured in 1,662 and 1,193 patients, respectively, by immunoturbidimetry. Interestingly, a relationship between CRP and CRP serum levels at diagnosis and at the time of the carotid ultrasonography was disclosed. However, no statistically significant differences were found when CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 were evaluated according to the presence/absence of CV events, carotid plaques and cIMT after adjustment. Our results do not confirm an association between these genes and CV disease in RA.enArtritis reumatoideAterosclerosisProteína c-reactivaGrosor intima-media carotídeoGenotipoHumanosPolimorfismo genéticoMedical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Arthritis, RheumatoidMedical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis::AtherosclerosisMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Albumins::C-Reactive ProteinMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Ultrasonography::Carotid Intima-Media ThicknessMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::GenotypeMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Geneticresearch article27534721open access10.1038/srep319792045-2322PMC4989194