Ubago-Guisado, EstherGracia-Marco, LuisMedrano, MaríaCadenas-Sanchez, CristinaArenaza, LideMigueles, Jairo HMora-Gonzalez, JoseTobalina, IgnacioEscolano-Margarit, Maria VictoriaOses, MaddiMartín-Matillas, MiguelLabayen, IdoiaOrtega, Francisco B2023-02-082023-02-082019-12-10http://hdl.handle.net/10668/14807To examine whether areal bone mineral density (aBMD) differs between metabolically healthy (MHO) and unhealthy (MUO) overweight/obese children and to examine the role of moderate-to-vigorous physical activity (MVPA) and cardiorespiratory fitness (CRF) in this association. A cross-sectional study was developed in 188 overweight/obese children (10.4 ± 1.2 years) from the ActiveBrains and EFIGRO studies. Participants were classified as MHO or MUO based on Jolliffe and Janssen's metabolic syndrome cut-off points for triglycerides, glucose, high-density cholesterol and blood pressure. MVPA and CRF were assessed by accelerometry and the 20-m shuttle run test, respectively. Body composition was measured by dual-energy X-ray absorptiometry. In model 1 (adjusted for sex, years from peak high velocity, stature and lean mass), MHO children had significantly higher aBMD in total body less head (Cohen's d effect size, ES = 0.34), trunk (ES = 0.43) and pelvis (ES = 0.33) than MUO children. These differences were attenuated once MVPA was added to model 1 (model 2), and most of them disappeared once CRF was added to the model 1 (model 3). This novel research shows that MHO children have greater aBMD than their MUO peers. Furthermore, both MVPA and more importantly CRF seem to partially explain these findings.enAbsorptiometry, PhotonBlood GlucoseBone DensityCardiorespiratory FitnessCase-Control StudiesChildCholesterol, HDLCross-Sectional StudiesExerciseFemaleHumansMaleObesityOverweightTriglyceridesresearch article31822016open access10.1038/s41390-019-0708-x1530-0447https://academica-e.unavarra.es/xmlui/bitstream/2454/36986/1/2020020102_Ubago_DifferencesAreal.pdf