Monge Garcia, Manuel IgnacioJian, ZhongpingSettels, Jos JHunley, CharlesCecconi, MaurizioHatib, FerasPinsky, Michael R2025-01-072025-01-072018-11-29https://hdl.handle.net/10668/25051Maximal left ventricular (LV) pressure rise (LV dP/dtmax), a classical marker of LV systolic function, requires LV catheterization, thus surrogate arterial pressure waveform measures have been proposed. We compared LV and arterial (femoral and radial) dP/dtmax to the slope of the LV end-systolic pressure-volume relationship (Ees), a load-independent measure of LV contractility, to determine the interactions between dP/dtmax and Ees as loading and LV contractility varied. We measured LV pressure-volume data using a conductance catheter and femoral and radial arterial pressures using a fluid-filled catheter in 10 anesthetized pigs. Ees was calculated as the slope of the end-systolic pressure-volume relationship during a transient inferior vena cava occlusion. Afterload was assessed by the effective arterial elastance. The experimental protocol consisted of sequentially changing afterload (phenylephrine/nitroprusside), preload (bleeding/fluid bolus), and contractility (esmolol/dobutamine). A linear-mixed analysis was used to assess the contribution of cardiac (Ees, end-diastolic volume, effective arterial elastance, heart rate, preload-dependency) and arterial factors (total vascular resistance and arterial compliance) to LV and arterial dP/dtmax. Both LV and arterial dP/dtmax allowed the tracking of Ees changes, especially during afterload and contractility changes, although arterial dP/dtmax was lower compared to LV dP/dtmax (bias 732 ± 539 mmHg⋅s- 1 for femoral dP/dtmax, and 625 ± 501 mmHg⋅s- 1 for radial dP/dtmax). Changes in cardiac contractility (Ees) were the main determinant of LV and arterial dP/dtmax changes. Although arterial dP/dtmax is a complex function of central and peripheral arterial factors, radial and particularly femoral dP/dtmax allowed reasonably good tracking of LV contractility changes as loading and inotropic conditions varied.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Arterial pressureContractilityLeft ventricular functiondP/dtmaxAdrenergic beta-1 Receptor AntagonistsAnimalsCardiotonic AgentsCatheterization, Central VenousMyocardial ContractionNitroprussidePhenylephrinePropanolaminesSwineVasodilator AgentsVentricular Function, LeftWeights and Measuresresearch article30486866open access10.1186/s13054-018-2260-11466-609XPMC6262953https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-018-2260-1https://pmc.ncbi.nlm.nih.gov/articles/PMC6262953/pdf