Boutriq, SoukainaGonzález-González, AliciaPlaza-Andrades, IsaacLaborda-Illanes, AuroraSánchez-Alcoholado, LidiaPeralta-Linero, JesúsDomínguez-Recio, María EmiliaBermejo-Pérez, María JoséLavado-Valenzuela, RocíoAlba, EmilioQueipo-Ortuño, María Isabel2022-05-202022-05-202021-07-14Boutriq S, González-González A, Plaza-Andrades I, Laborda-Illanes A, Sánchez-Alcoholado L, Peralta-Linero J, et aI. Gut and Endometrial Microbiome Dysbiosis: A New Emergent Risk Factor for Endometrial Cancer. J Pers Med. 2021 Jul 14;11(7):659http://hdl.handle.net/10668/3658Endometrial cancer is one of the most common gynaecological malignancies worldwide. Histologically, two types of endometrial cancer with morphological and molecular differences and also therapeutic implications have been identified. Type I endometrial cancer has an endometrioid morphology and is estrogen-dependent, while Type II appears with non-endometrioid differentiation and follows an estrogen-unrelated pathway. Understanding the molecular biology and genetics of endometrial cancer is crucial for its prognosis and the development of novel therapies for its treatment. However, until now, scant attention has been paid to environmental components like the microbiome. Recently, due to emerging evidence that the uterus is not a sterile cavity, some studies have begun to investigate the composition of the endometrial microbiome and its role in endometrial cancer. In this review, we summarize the current state of this line of investigation, focusing on the relationship between gut and endometrial microbiome and inflammation, estrogen metabolism, and different endometrial cancer therapies.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Endometrial cancerEndometrial microbiomeGut microbiomeDysbiosisEstrogen metabolismEstrobolomeInflammationAntitumour treatmentPrebioticsProbioticsMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Female::Uterine Neoplasms::Endometrial NeoplasmsMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::EstrogensMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::PrognosisMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biochemistry::Molecular BiologyMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::InflammationMedical Subject Headings::Phenomena and Processes::Microbiological Phenomena::MicrobiotaMedical Subject Headings::Anatomy::Urogenital System::Genitalia::Genitalia, Female::Uterusreview article34357126open accessNeoplasias endometrialesMicrobioma gastrointestinalDisbiosisInflamaciónPrebióticosProbióticos10.3390/jpm110706592075-4426PMC8304951