García Pérez, José LuisAlarcón-Riquelme, Marta E2023-01-252023-01-252017http://hdl.handle.net/10668/11566In this issue of Cell Stem Cell, Thomas et al. (2017) define the nature of accumulated ssDNA present in the neuron and astrocyte cytoplasm of TREX1 mutated stem cell-derived organoids. Accumulated ssDNAs are derived from LINE-1 endogenous retroelements, providing new clues as to the development of Aicardi-Goutières syndrome in the neural system.enAnimalsAutoimmune DiseasesAutoimmune Diseases of the Nervous SystemBrainDinosaursHumansPhosphoproteinsStem Cellsresearch article28886359open access10.1016/j.stem.2017.08.0101875-9777http://www.cell.com/article/S1934590917303284/pdf