García-Aranda, MarilinaPérez-Ruiz, ElisabetRedondo, Maximino2023-01-252023-01-252018-12-08http://hdl.handle.net/10668/13309Abstract: According to the World Health Organization (WHO), cancer is a leading cause of death worldwide. The identification of novel targets for cancer treatment is an area of intense work that has led Bcl-2 over-expression to be proposed as one of the hallmarks of cancer and Bcl-2 inhibition as a promising strategy for cancer treatment. In this review, we describe the different pathways related to programmed cell death, the role of Bcl-2 family members in apoptosis resistance to anti-cancer treatments, and the potential utility of Bcl-2 inhibitors to overcome resistance to chemo- and immunotherapy.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Bcl-2apoptosiscancerchemotherapyimmunotherapyinhibitionresistanceAnimalsApoptosisDrug Resistance, NeoplasmHumansImmunotherapyModels, BiologicalNeoplasmsProto-Oncogene Proteins c-bcl-2research article30544835open access10.3390/ijms191239501422-0067PMC6321604https://www.mdpi.com/1422-0067/19/12/3950/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321604/pdf