Puentes-Pardo, Jose D.Moreno-SanJuan, SaraCarazo, ÁngelLeón, Josefa2022-04-202022-04-202020-12-02Puentes-Pardo JD, Moreno-SanJuan S, Carazo Á, León J. Heme Oxygenase-1 in Gastrointestinal Tract Health and Disease. Antioxidants (Basel). 2020 Dec 2;9(12):1214http://hdl.handle.net/10668/3541Heme oxygenase 1 (HO-1) is the rate-limiting enzyme of heme oxidative degradation, generating carbon monoxide (CO), free iron, and biliverdin. HO-1, a stress inducible enzyme, is considered as an anti-oxidative and cytoprotective agent. As many studies suggest, HO-1 is highly expressed in the gastrointestinal tract where it is involved in the response to inflammatory processes, which may lead to several diseases such as pancreatitis, diabetes, fatty liver disease, inflammatory bowel disease, and cancer. In this review, we highlight the pivotal role of HO-1 and its downstream effectors in the development of disorders and their beneficial effects on the maintenance of the gastrointestinal tract health. We also examine clinical trials involving the therapeutic targets derived from HO-1 system for the most common diseases of the digestive system.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Heme oxygenaseGastrointestinal tractCancerDiabetesPancreatitisInflammatory bowel diseasePeptic ulcer diseaseFatty liver diseaseFerroptosisHemo-oxigenasa 1Tracto gastrointestinalNeoplasiasEnfermedades inflamatorias del intestinoÚlcera pépticaEnfermedad del hígado graso no alcohólicoDiabetes mellitusMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxygenases::Mixed Function Oxygenases::Heme Oxygenase (Decyclizing)::Heme Oxygenase-1Medical Subject Headings::Anatomy::Digestive System::Gastrointestinal TractMedical Subject Headings::Diseases::NeoplasmsMedical Subject Headings::Diseases::Endocrine System Diseases::Diabetes MellitusMedical Subject Headings::Diseases::Digestive System Diseases::Pancreatic Diseases::PancreatitisMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel DiseasesMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Peptic UlcerMedical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Fatty LiverMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humansreview article33276470open access10.3390/antiox91212142076-3921PMC7760122