Doña, InmaculadaTorres, Maria Jose2023-02-092023-02-092021-02-23Doña I, Torres MJ. A new oral kallikrein inhibitor for long-term prophylaxis of hereditary angioedema. Allergy. 2021 Jun;76(6):1619-1620http://hdl.handle.net/10668/17250Hereditary angioedema (HAE) is a rare inherited chronic disease characterized by unpredictable recurrent attacks of cutaneous and submucosal swelling potentially involving airways, frequently upper ones, and compromising patient's life. This implies a serious health problem with significant disease burden and reduced life quality. This disease presents a great clinical variability and different endotypes, hampering diagnosis and requiring a personalized treatment. The primary mediator of swelling in most phenotypes is bradykinin, which increases vasodilation and vascular permeability by binding to the bradykinin B2 receptor.enVasodilationChronic DiseaseAngioedemas, HereditaryQuality of LifeBradykininCost of IllnessCapillary PermeabilityAndalusian Center for Nanomedicine and Biotechnology-BIONANDAngioedemas, HereditaryAntibodies, Monoclonal, HumanizedComplement C1 Inhibitor ProteinHumansPlasma Kallikreinresearch article33641193Restricted accessAngioedemas hereditariosCosto de enfermedadEnfermedad crónicaVasodilataciónBradiquininaPermeabilidad capilar10.1111/all.147981398-9995