Varela-Lopez, BenxaminCruz-Gomez, Alvaro JavierLojo-Seoane, CristinaDiaz, FernandoPereiro, A XZurron, MontserratLindín, MonicaGaldo-Alvarez, Santiago2023-05-032023-05-032022-05-07Varela-López B, Cruz-Gómez ÁJ, Lojo-Seoane C, Díaz F, Pereiro AX, Zurrón M, et al. Cognitive reserve, neurocognitive performance, and high-order resting-state networks in cognitively unimpaired aging. Neurobiol Aging. 2022 Sep;117:151-164http://hdl.handle.net/10668/22422Cognitive Reserve (CR) is considered a protective factor during the aging process. However, although CR is a multifactorial construct, it has been operationalized in a unitary way (years of formal education or IQ). In the present study, a validated measure to categorize CR holistically (Cognitive Reserve Index Questionnaire) was used to evaluate the resting-state functional connectivity in 77 cognitively unimpaired participants aged 50 years and over with high and low CR, and matched brain global atrophy levels. The connectivity of networks linked to attentional (Dorsal Attention Network -DAN-) and executive (Frontal-Parietal Control Network -FPCN-) processes were evaluated by the combination of Independent Component Analysis and seed-based approaches, since these networks have been proposed as candidates to underlie the protective effect of CR in the aging context. Participants with high CR showed an increase of the connectivity in the FPCN and a decrease in the DAN with respect to the low CR group, correlating with neuropsychological scores and supporting that high CR is related to a better neurocognitive preservation during aging.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Cognitive reserveDANFPCNHealthy agingResting-state functional magnetic resonanceAgedAgingAtrophyBrainBrain mappingCognitive reserveHumansMagnetic resonance imagingMiddle agedNeural pathwaysNeuropsychological testsresearch article35759984open accessAtrofiaEncéfaloEnvejecimientoImagen por resonancia magnéticaMapeo encefálicoPruebas neuropsicológicasReserva cognitivaVías nerviosas10.1016/j.neurobiolaging.2022.05.0121558-1497https://minerva.usc.es/xmlui/bitstream/10347/29095/1/2022_neuofagi_varela_cognitive.pdf