Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity.

Rogati, FedericaMillan, EstrellaAppendino, GiovanniCorrea, AlejandroCaprioglio, DiegoMinassi, AlbertoMuñoz, Eduardo2023-01-252023-01-252019-01-08Rogati F, Millán E, Appendino G, Correa A, Caprioglio D, Minassi A, et al. Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity. ACS Med Chem Lett. 2019 Jan 8;10(4):606-6101948-5875http://hdl.handle.net/10668/13847The sesquiterpene-coumarin ether samarcandone provided a suitable framework to replace the apocarotenoid A-C ring system of strigol (1), replicating, after linking to a butenolide moiety, the activity of the natural phytohormone on Nrf2 and also showing potent NF-kB inhibitory activity, overall modulating two critical pathways of inflammation and cancer.enStrigolactonesTerpenesNrf2NF-κBNF-kappa BEtherPlant growth regulatorsButenolideNF-E2-related factor 2Critical pathwaysEthyl ethersIdentification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity.research article30996804open accessFN-kappa BFactor 2 relacionado con NF-E2Reguladores del crecimiento de las plantasVías clínicasÉterÉteres de etila10.1021/acsmedchemlett.8b00604PMC6467025https://europepmc.org/articles/pmc6467025?pdf=renderhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467025/pdf