Duque-Sosa, PaulaMartínez-Urbistondo, DiegoEcharri, GemmaCallejas, RaquelIribarren, María JosefaRábago, GregorioMonedero, PabloSpanish group of renal dysfunction in cardiac surgery (GEDRCC-2)2025-01-072025-01-072017-02-22https://hdl.handle.net/10668/25301Perioperative anemia is an important risk factor for cardiac surgery-associated acute kidney injury (CSA-AKI). Nonetheless, the severity of the anemia and the time in the perioperative period in which the hemoglobin level should be considered as a risk factor is conflicting. The present study introduces the concept of perioperative hemoglobin area under the curve (pHb-AUC) as a surrogate marker of the evolution of perioperative hemoglobin concentration. Through a retrospective analysis of prospectively collected data, we assessed this new variable as a risk factor for the development of acute kidney injury after cardiac surgery in 966 adult patients who underwent cardiac surgery with cardiopulmonary bypass, at twenty-three academic hospitals in Spain. Exclusion criteria were patients on renal replacement therapy, who needed a reoperation because of bleeding and/or with missing perioperative hemoglobin or creatinine values. Using a multivariate regression analysis, we found that a pHb-AUCenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Acute Kidney InjuryAgedArea Under CurveCardiac Surgical ProceduresFemaleHemoglobinsHumansLength of StayMaleMiddle AgedPerioperative PeriodPostoperative ComplicationsPredictive Value of TestsPrognosisProhibitinsRenal InsufficiencyRetrospective StudiesRisk FactorsSpainresearch article28225801open access10.1371/journal.pone.01720211932-6203PMC5321429https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0172021&type=printablehttps://pmc.ncbi.nlm.nih.gov/articles/PMC5321429/pdf