Geribaldi-Doldán, NoeliaHervás-Corpión, IratiGómez-Oliva, RicardoDomínguez-García, SamuelRuiz, Félix A.Iglesias-Lozano, IreneCarrascal, LiviaPardillo-Díaz, RicardoGil-Salú, José L.Nunez-Abades, PedroValor, Luis M.Castro, Carmen2022-11-292022-11-292021-04-04Geribaldi-Doldán N, Hervás-Corpión I, Gómez-Oliva R, Domínguez-García S, Ruiz FA, Iglesias-Lozano I, et al. Targeting Protein Kinase C in Glioblastoma Treatment. Biomedicines. 2021 Apr 4;9(4):381http://hdl.handle.net/10668/4420Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor and is associated with a poor prognosis. Despite the use of combined treatment approaches, recurrence is almost inevitable and survival longer than 14 or 15 months after diagnosis is low. It is therefore necessary to identify new therapeutic targets to fight GBM progression and recurrence. Some publications have pointed out the role of glioma stem cells (GSCs) as the origin of GBM. These cells, with characteristics of neural stem cells (NSC) present in physiological neurogenic niches, have been proposed as being responsible for the high resistance of GBM to current treatments such as temozolomide (TMZ). The protein Kinase C (PKC) family members play an essential role in transducing signals related with cell cycle entrance, differentiation and apoptosis in NSC and participate in distinct signaling cascades that determine NSC and GSC dynamics. Thus, PKC could be a suitable druggable target to treat recurrent GBM. Clinical trials have tested the efficacy of PKCβ inhibitors, and preclinical studies have focused on other PKC isozymes. Here, we discuss the idea that other PKC isozymes may also be involved in GBM progression and that the development of a new generation of effective drugs should consider the balance between the activation of different PKC subtypes.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/GlioblastomaProtein kinase CGlioma stem cellsNeurogenesisNeural stem cellsTemozolomideEnzastaurinEpidermal growth factor receptorNeuregulinBrain tumorApoptosisCell cycleProteína quinasa CCélulas madreNeurogénesisCélulas-madre neuralesTemozolomidaReceptores ErbBNeurregulinasNeoplasias encefálicasCiclo celularMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Germ Cell and Embryonal::Neuroectodermal Tumors::Neoplasms, Neuroepithelial::Glioma::Astrocytoma::GlioblastomaMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::IsoenzymesMedical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Brain NeoplasmsMedical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem CellsMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::ApoptosisMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::Protein Kinase CMedical Subject Headings::Anatomy::Cells::Stem Cells::Neural Stem CellsMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell CycleMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::PrognosisMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humansreview article33916593open access10.3390/biomedicines90403812227-9059PMC8067000