Vega, Francisco MRidley, Anne J2025-01-072025-01-072016-11-22https://hdl.handle.net/10668/25394RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes. Its multiple roles will be discussed in this review.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Rho GTPasesRhoBcancer progressiondevelopmentmembrane traffickingAmino Acid SequenceAnimalsDiseaseGrowth and DevelopmentHumansNeoplasmsNeovascularization, PhysiologicrhoB GTP-Binding Proteinresearch article27875099open access10.1080/21541248.2016.12535282154-1256PMC5997158https://www.tandfonline.com/doi/pdf/10.1080/21541248.2016.1253528?needAccess=truehttps://pmc.ncbi.nlm.nih.gov/articles/PMC5997158/pdf