Esteban, FranciscoRamos-Garcia, PabloMuñoz, MiguelGonzalez-Moles, Miguel Angel2023-05-032023-05-032021-12-27Esteban F, Ramos-García P, Muñoz M, González-Moles MÁ. Substance P and Neurokinin 1 Receptor in Chronic Inflammation and Cancer of the Head and Neck: A Review of the Literature. Int J Environ Res Public Health. 2021 Dec 30;19(1):375.http://hdl.handle.net/10668/21013Head and neck cancer is a growing worldwide public health problem, accounting for approximately 1,500,000 new cases and 500,000 deaths annually. Substance P (SP) is a peptide of the tachykinin family, which has roles related to a large number of physiological mechanisms in humans. The implications of SP in carcinogenesis have recently been reported through the stimulation of the neurokinin 1 receptor (NK1R), or directly, through the effects derived from the constitutive activation of NK1R. Consequently, SP/NK1R seems to play relevant roles in cancer, upregulating cell proliferation, cell migration and chronic inflammation, among other oncogenic actions. Furthermore, there is growing evidence pointing to a central role for SP in tumour progression, singularly so in laryngeal and oral squamous cell carcinomas. The current narrative review of the literature focuses on the relationship between the SP/NK1R system and chronic inflammation and cancer in the head-and-neck region. We described a role for SP/NK1R in the transition from chronic inflammation of the head and neck mucosa, to preneoplastic and neoplastic transformation and progression.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/NK1Rchronic inflammationhead and neck cancersquamous cell carcinomasubstance PCell ProliferationHumansInflammationNeoplasmsReceptors, Neurokinin-1Substance Presearch article35010633open accessSustancia PReceptores de neuroquinina-1Proliferación celularNeoplasiasInflamaciónHumanos10.3390/ijerph190103751660-4601PMC8751191https://www.mdpi.com/1660-4601/19/1/375/pdf?version=1640859263https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8751191/pdf