Rodríguez-Capitán, JorgeSánchez-Pérez, AndrésBallesteros-Pradas, SaraMillán-Gómez, MercedesCardenal-Piris, RosaOneto-Fernández, ManuelGutiérrez-Alonso, LolaRivera-López, RicardoGuisado-Rasco, AgustínCano-García, MacarenaGutiérrez-Bedmar, MarioJiménez-Navarro, Manuel2025-01-072025-01-072021-04-252077-0383https://hdl.handle.net/10668/27187The clinical significance of non-obstructive coronary artery disease is the subject of debate. Our objective was to evaluate the long-term cardiovascular prognosis associated with non-obstructive coronary artery disease in patients undergoing coronary angiography, and to conduct a stratification by sex, diabetes, and clinical indication. We designed a multi-centre retrospective longitudinal observational study of 3265 patients that were classified into three groups: normal coronary arteries (lesion 70%, 1196 patients). During a mean follow-up of 43 months, we evaluated a combined cardiovascular event: acute myocardial infarction, stroke, hospitalization for heart failure, or cardiovascular death. Multivariable-adjusted Cox proportional hazard models showed a worse prognosis in patients with non-obstructive coronary artery disease, in comparison with patients of normal coronary arteries group, in the total population (hazard ratio 1.72, 95% confidence interval 1.23-2.39; p for trendenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/acute coronary syndromecoronary angiographycoronary artery diseasediabetes mellitussexresearch article33923110open access10.3390/jcm10091863PMC8123418https://www.mdpi.com/2077-0383/10/9/1863/pdf?version=1619400339https://pmc.ncbi.nlm.nih.gov/articles/PMC8123418/pdf