Pinazo-Durán, Maria DGarcía-Medina, Jose JSanz-González, Silvia MO'Connor, Jose ECasaroli-Marano, Ricardo PValero-Velló, MarLópez-Gálvez, MaribelPeris-Martínez, CristinaZanón-Moreno, VicenteDiaz-Llopis, Manuel2025-01-072025-01-072021-04-192075-4418https://hdl.handle.net/10668/24433The purpose of this study was to identify circulating biomarkers of recurrent non-infectious anterior uveitis (NIAU), and to address the anti-inflammatory effects of triglyceride containing docosahexaenoic acid (DHA-TG). A prospective multicenter study was conducted in 72 participants distributed into: patients diagnosed with recurrent NIAU in the quiescence stage (uveitis group (UG); n = 36) and healthy controls (control group (CG); n = 36). Each group was randomly assigned to the oral supplementation of one pill/day (+) containing DHA-TG (n = 18) or no-pill condition (-) (n = 17) for three consecutive months. Data from demographics, risk factors, comorbidities, eye complications and therapy were recorded. Blood was collected and processed to determine pro-inflammatory biomarkers by bead-base multiplex assay. Statistical processing with multivariate statistical analysis was performed. The mean age was 50, 12 (10, 31) years. The distribution by gender was 45% males and 55% females. The mean number of uveitis episodes was 5 (2). Higher plasma expression of interleukin (IL)-6 was detected in the UG versus the CG (p = 5 × 10-5). Likewise, significantly higher plasma levels were seen for IL-1β, IL-2, INFγ (p = 10-4), and TNFα (p = 2 × 10-4) in the UG versus the CG. Significantly lower values of the above molecules were found in the +DHA-TG than in the -DHA-TG subgroups, after 3 months of follow-up, TNFα (p = 10-7) and IL-6 (p = 3 × 10-6) being those that most significantly changed. Signatures of circulating inflammatory mediators were obtained in the quiescent stage of recurrent NIAU patients. This 3-month follow-up strongly reinforces that a regular oral administration of DHA-TG reduces the inflammatory load and may potentially supply a prophylaxis-adjunctive mediator for patients at risk of uveitis vision loss.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/cytokinesomega-3 fatty acidsrecurrent anterior non-infectious uveitistriglyceride of docosahexaenoic acidresearch article33921773open access10.3390/diagnostics11040724PMC8072877https://www.mdpi.com/2075-4418/11/4/724/pdf?version=1618833804https://pmc.ncbi.nlm.nih.gov/articles/PMC8072877/pdf