Casuso, Rafael APlaza-Díaz, JulioRuiz-Ojeda, Francisco JAragón-Vela, JerónimoRobles-Sanchez, CándidoNordsborg, Nikolai BHebberecht, MarinaSalmeron, Luis MHuertas, Jesus R2023-01-252023-01-252017-10-03http://hdl.handle.net/10668/11643We aimed to test whether high-intensity high-volume training (HIHVT) swimming would induce more robust signaling than sprint interval training (SIT) swimming within the m. triceps brachii due to lower metabolic and oxidation. Nine well-trained swimmers performed the two training procedures on separate randomized days. Muscle biopsies from m. triceps brachii and blood samples were collected at three different time points: a) before the intervention (pre), b) immediately after the swimming procedures (post) and c) after 3 h of rest (3 h). Hydroperoxides, creatine kinase (CK), and lactate dehydrogenase (LDH) were quantified from blood samples, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and the AMPKpTHR172/AMPK ratio were quantified by Western blot analysis. PGC-1α, sirtuin 3 (SIRT3), superoxide-dismutase 2 (SOD2), and vascular endothelial growth factor (VEGF) mRNA levels were also quantified. SIT induced a higher release of LDH (penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AMP-Activated Protein KinasesAntioxidantsBlotting, WesternHeart RateHumansLactatesLipid PeroxidationMaleMuscle, SkeletalOxidative StressPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaRNA, MessengerReal-Time Polymerase Chain ReactionSignal TransductionSwimmingTranscription, Geneticresearch article28973039open access10.1371/journal.pone.01854941932-6203PMC5626429https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0185494&type=printablehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626429/pdf