Jiménez-Sousa, María ÁngelesGómez-Moreno, Ana ZaidaPineda-Tenor, DanielSánchez-Ruano, Juan JoséArtaza-Varasa, TomasMartin-Vicente, MaríaFernández-Rodríguez, AmandaMartínez, IsidoroResino, Salvador2023-01-252023-01-252019-04-09http://hdl.handle.net/10668/13809: The Duffy antigen receptor for chemokines (DARC) rs12075 polymorphism regulates leukocyte trafficking and proinflammatory chemokine homeostasis. Hepatitis C virus (HCV)-mediated liver fibrosis is associated with an uncontrolled inflammatory response. In this study, we evaluate the association between the DARC rs12075 polymorphism and liver stiffness progression in HCV-infected patients. We carried out a retrospective cohort study (repeated measures design) in 208 noncirrhotic patients with chronic hepatitis C (CHC) who had at least two liver stiffness measurements (LSM) with a separation of at least 12 months. We used generalized linear models to analyze the association between DARC rs12075 polymorphism and outcome variables. During a follow-up of 46.6 months, the percentage of patients with stages of fibrosis F0/F1 decreased (penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/DARCchronic hepatitis Ccirrhosishepatic fibrosisliver stiffnesssingle nucleotide polymorphismsAdultDuffy Blood-Group SystemFemaleHepatitis C, ChronicHumansLiverLiver CirrhosisMaleMiddle AgedPolymorphism, Single NucleotideReceptors, Cell Surfaceresearch article30970632open access10.3390/biom90401432218-273XPMC6523653https://www.mdpi.com/2218-273X/9/4/143/pdf?version=1555669940https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523653/pdf