Aragón-Vela, JerónimoFontana, LuisCasuso, Rafael A.Plaza-Díaz, JulioHuertas, Jesús R.2022-11-212022-11-212021Aragón-Vela J, Fontana L, Casuso RA, Plaza-Díaz J, R Huertas J. Differential inflammatory response of men and women subjected to an acute resistance exercise. Biomed J. 2021 Jun;44(3):338-345.2319-4170http://hdl.handle.net/10668/4382Background The purpose of this study was to investigate the inflammatory response, lipid peroxidation and muscle damage in men and women athletes subjected to an acute resistance exercise. Methods Twenty college athletes (10 men and 10 women) performed a half-squat exercise consisting of five incremental intensities: 20%, 40%, 60%, 80% and 100% of the one-repetition maximum. Blood samples were collected at rest, 15 min and 24 h post-test. The concentration of lipid peroxidation markers and the activities of a skeletal muscle damage marker and a cardiac muscle damage marker were determined in serum. Serum α-actin was measured as a marker of sarcomere damage. Serum levels of interleukin-6, interleukin-10, and tumor necrosis factor alpha were determined to assess the inflammatory response. Results Interleukin-6 levels were higher at 24 h post-test than at rest and 15 min post-test in men (p < 0.05). Moreover, men showed significantly higher hydroperoxide levels in response to resistance exercise at 24 h post-test than at 15 min post-test (p < 0.05). No differences were found in muscle damage parameters regardless of sex or the time point of the test. No differences regarding the studied variables were found when comparing among different time points in women. Conclusion Our results show a larger influence of half-squat exercises on the release of IL6 and on lipid peroxidation in men than in women at equivalent workloads.enAtribución 4.0 InternacionalAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/IL6Serum interleukinsInflammatory responseSex differencesStrength exerciseResistance trainingLipid peroxidationAthletesInterleucina-6InflamaciónCaracterísticas sexualesEntrenamiento de fuerzaPeroxidación de lípidoAtletasMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Biomarkers, PharmacologicalMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity::ExerciseMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Lipid PeroxidationMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Anatomy::Musculoskeletal System::Muscles::Muscle, SkeletalMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Physical Therapy Modalities::Exercise Therapy::Resistance TrainingMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-6Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins::Interleukin-10Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors::Tumor Necrosis Factor-alphaMedical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Microfilament Proteins::ActinsMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Oxygen Compounds::Oxides::Peroxides::Hydrogen PeroxideMedical Subject Headings::Anatomy::Tissues::Muscles::Muscle, Striated::Myofibrils::SarcomeresMedical Subject Headings::Health Care::Health Services Administration::Organization and Administration::Personnel Management::WorkloadMedical Subject Headings::Persons::Persons::AthletesMedical Subject Headings::Anatomy::Cardiovascular System::Heart::MyocardiumMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Sex Characteristicsresearch article34140269Acceso abierto10.1016/j.bj.2020.02.0052320-2890PMC8358195