Prados, GermánMiró, ElenaMartínez, M PilarSánchez, Ana IPichot, VincentMedina-Casado, MartaChouchou, Florian2023-05-032023-05-032022-07-20Prados G, Miró E, Martínez MP, Sánchez AI, Pichot V, Medina-Casado M, et al. Effect of Cognitive-Behavioral Therapy on Nocturnal Autonomic Activity in Patients with Fibromyalgia: A Preliminary Study. Brain Sci. 2022 Jul 20;12(7):947.2076-3425http://hdl.handle.net/10668/20855Objective: fibromyalgia is a complex chronic pain syndrome characterized by widespread musculoskeletal pain, insomnia and autonomic alterations. Cognitive-behavioral therapy (CBT) is regarded as a promising treatment in fibromyalgia, but its impact on autonomic function remains uncertain. In this research, we studied the effect of CBT on autonomic functions in fibromyalgia. Methods: Twenty-five participants underwent overnight polysomnographic recordings before and after CBT programs focused on pain (CBT-P) or a hybrid modality focused on pain and insomnia (CBT-C). Sleep quality, daily pain, depression and anxiety were assessed by self-reported questionnaires. We analyzed heart rate variability (HRV) using high-frequency power (HF) as a marker for parasympathetic activity, and low-frequency power (LF) and the LF/HF ratio as relative sympathetic markers during wakefulness and at each sleep stage. Results: After treatment, 14 patients (/25, 58.0%) reported improvement in their sleep: 6 in the CBT-P condition (/12, 50%), and 8 in the CBT-C condition (/13, 61.5%). We found that, regardless of the type of CBT, patients who reported improvement in sleep quality (n = 14, 58%) had an increase in HF during stages N2 (penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/fibromyalgiaheart rate variabilityinsomniapsychological treatmentHumansSleep Initiation and Maintenance DisordersFibromyalgiaWakefulnessChronic PainHeart RateSelf ReportSleep QualityMusculoskeletal PainPolysomnographyDepressionSleep StagesSurveys and QuestionnairesAnxietyCognitive Behavioral Therapyresearch article35884753open accessAnsiedadAutoinformeCalidad del sueñoDepresiónDolor crónicoDolor musculoesqueléticoFases del sueñoFibromialgiaFrecuencia cardíacaPolisomnografíaVigilia10.3390/brainsci12070947PMC9320055https://www.mdpi.com/2076-3425/12/7/947/pdf?version=1658296818https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320055/pdf