Alten, RiekeMariette, XavierLorenz, Hanns-MartinNüßlein, HubertGaleazzi, MauroNavarro, FedericoChartier, MelanieHeitzmann, JuliaPoncet, CoralieRauch, ChristianeLe Bars, Manuela2023-01-252023-01-252019-02-21http://hdl.handle.net/10668/13603Evaluate abatacept retention over 2 years in the AbataCepT In rOutiNe clinical practice (ACTION) study. ACTION was an international, observational study of patients with moderate-to-severe rheumatoid arthritis (RA) who initiated intravenous abatacept. Crude abatacept retention rates over 2 years were estimated using Kaplan-Meier analyses in biologic-naive and -failure patients. Clinically relevant risk factors and significant prognostic factors for retention were evaluated using a Cox proportional hazards multivariable model. Overall, 2350/2364 enrolled patients were evaluable; 673 (28.6%) were biologic naive and 1677 (71.4%) had prior biologic failure (1 biologic, 728/1677 [43.4%]; ≥ 2 biologics, 949/1677 [56.6%]). Abatacept retention rate (95% confidence interval [CI]) at 2 years was 47.9% (45.7, 50.0): 54.5% (50.4, 58.3) for biologic-naive vs 45.2% (42.7, 47.7) for biologic-failure patients (log-rank P  Abatacept initiation as earlier vs later line of therapy in RA may achieve higher 2-year retention rates. RF and anti-CCP seropositivity could predict increased abatacept retention, irrespective of treatment line. NCT02109666.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/BiologicEfficacyPredictorRemissionRheumatoid arthritisAbataceptAdrenal Cortex HormonesAgedAntirheumatic AgentsArthritis, RheumatoidCohort StudiesDrug Therapy, CombinationFemaleHumansInternationalityKaplan-Meier EstimateMaleMethotrexateMiddle AgedMultivariate AnalysisProportional Hazards ModelsRheumatoid FactorTreatment Outcomeresearch article30790095open access10.1007/s10067-019-04449-w1434-9949https://link.springer.com/content/pdf/10.1007/s10067-019-04449-w.pdf