Results from the ERA-EDTA Registry indicate a high mortality due to COVID-19 in dialysis patients and kidney transplant recipients across Europe.

Jager, Kitty JKramer, AnnekeChesnaye, Nicholas CCouchoud, CécileSánchez-Álvarez, J EmilioGarneata, LilianaCollart, FrédericHemmelder, Marc HAmbühl, PatriceKerschbaum, JuliaLegeai, CamilleDel Pino Y Pino, María DoloresMircescu, GabrielMazzoleni, LionelHoekstra, TinyWinzeler, RebeccaMayer, GertStel, Vianda SWanner, ChristophZoccali, CarmineMassy, Ziad A2023-02-092023-02-092020-10-15http://hdl.handle.net/10668/16321The aim of this study was to investigate 28-day mortality after COVID-19 diagnosis in the European kidney replacement therapy population. In addition, we determined the role of patient characteristics, treatment factors, and country on mortality risk with the use of ERA-EDTA Registry data on patients receiving kidney replacement therapy in Europe from February 1, 2020, to April 30, 2020. Additional data on all patients with a diagnosis of COVID-19 were collected from 7 European countries encompassing 4298 patients. COVID-19-attributable mortality was calculated using propensity score-matched historic control data and after 28 days of follow-up was 20.0% (95% confidence interval 18.7%-21.4%) in 3285 patients receiving dialysis and 19.9% (17.5%-22.5%) in 1013 recipients of a transplant. We identified differences in COVID-19 mortality across countries, and an increased mortality risk in older patients receiving kidney replacement therapy and male patients receiving dialysis. In recipients of kidney transplants ≥75 years of age, 44.3% (35.7%-53.9%) did not survive COVID-19. Mortality risk was 1.28 (1.02-1.60) times higher in transplant recipients compared with matched dialysis patients. Thus, the pandemic has had a substantial effect on mortality in patients receiving kidney replacement therapy, a highly vulnerable population due to underlying chronic kidney disease and a high prevalence of multimorbidity.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19attributable mortalitydialysiskidney replacement therapyregistriestransplantationAdolescentAdultAgedCOVID-19ChildChild, PreschoolEuropeFemaleHumansInfantKidney Failure, ChronicKidney TransplantationMaleMiddle AgedPandemicsPostoperative ComplicationsRegistriesRenal DialysisRisk FactorsYoung AdultResults from the ERA-EDTA Registry indicate a high mortality due to COVID-19 in dialysis patients and kidney transplant recipients across Europe.research article32979369open access10.1016/j.kint.2020.09.0061523-1755PMC7560263http://www.kidney-international.org/article/S0085253820310814/pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560263/pdf