Magán-Fernández, AntonioRasheed Al-Bakri, Sarmad MuayadO'Valle, FranciscoBenavides-Reyes, CristinaAbadía-Molina, FranciscoMesa, Francisco2022-07-152022-07-152020-06-19Magán-Fernández A, Rasheed Al-Bakri SM, O'Valle F, Benavides-Reyes C, Abadía-Molina F, Mesa F. Neutrophil Extracellular Traps in Periodontitis. Cells. 2020 Jun 19;9(6):1494http://hdl.handle.net/10668/3791Neutrophils are key cells of the immune system and have a decisive role in fighting foreign pathogens in infectious diseases. Neutrophil extracellular traps (NETs) consist of a mesh of DNA enclosing antimicrobial peptides and histones that are released into extracellular space following neutrophil response to a wide range of stimuli, such as pathogens, host-derived mediators and drugs. Neutrophils can remain functional after NET formation and are important for periodontal homeostasis. Periodontitis is an inflammatory multifactorial disease caused by a dysbiosis state between the gingival microbiome and the immune response of the host. The pathogenesis of periodontitis includes an immune-inflammatory component in which impaired NET formation and/or elimination can be involved, contributing to an exacerbated inflammatory reaction and to the destruction of gingival tissue. In this review, we summarize the current knowledge about the role of NETs in the pathogenesis of periodontitis.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Innate immunityPeriodontitisNeutrophil functionsNeutrophil extracellular trapsInmunidad innataNeutrófilosTrampas extracelularesMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNAMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Immunity, InnateMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::InflammationMedical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Granulocytes::NeutrophilsMedical Subject Headings::Diseases::Stomatognathic Diseases::Mouth Diseases::Periodontal Diseases::PeriodontitisMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Free Radicals::Reactive Oxygen SpeciesMedical Subject Headings::Anatomy::CellsMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins::HistonesMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::HomeostasisMedical Subject Headings::Organisms::Bacteria::Bacteroidetes::Bacteroidaceae::Porphyromonas::Porphyromonas gingivalisreview article32575367Acceso abierto10.3390/cells90614942073-4409PMC7349145