Baus-Domínguez, MGómez-Díaz, RTorres-Lagares, DCorcuera-Flores, J RRuiz-Villandiego, J CMachuca-Portillo, GGutiérrez-Pérez, J LSerrera-Figallo, M A2023-02-082023-02-082019-10-21http://hdl.handle.net/10668/14748Aware that Down Syndrome patients present among their clinical characteristics impaired immunity, the aim of this study is to identify the statistically significant differences in inflammation-related gene expression by comparing Down Syndrome patients with Periodontal Disease (DS+PD+) with Down Syndrome patients without Periodontal Disease (DS+PD-), and their relationship with periodontitis as a chronic oral inflammatory clinical feature. Case study and controls on eleven Down Syndrome patients (DS+PD+ vs. DS+PD-). RNA was extracted from peripheral blood using a Qiagen PAXgene Blood miRNA Kit when performing an oral examination. A search for candidate genes (92 selected) was undertaken on the total genes obtained using a Scientific GeneChip® Scanner 3000 (Thermo Fisher Scientific) and Clariom S solutions for human, mouse, and rat chips, with more than 20,000 genes annotated for measuring expression levels. Of the 92 inflammation-related genes taken initially, four genes showed a differential expression across both groups with a p value of There are differences in inflammation-related gene expression in Down Syndrome patients when comparing patients who present a state of chronic oral inflammation with patients with negative rates of periodontal disease.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Annexin A3B-Cell Activating FactorDown SyndromeFemaleHumansInflammationIntegrin beta3MalePeriodontal DiseasesPeriodontitisresearch article31772502open access10.1155/2019/45671061466-1861PMC6854216https://doi.org/10.1155/2019/4567106https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854216/pdf