de Jong, SimoneNewhouse, Stephen JPatel, HamelLee, SanghyuckDempster, DavidCurtis, CharlesPaya-Cano, JoseMurphy, DeclanWilson, C EllieHorder, JamieMendez, M AndreinaAsherson, PhilipRivera, MargaritaCostello, HelenMaltezos, StefanosWhitwell, SusannahPitts, MarkTye, CharlotteAshwood, Karen LBolton, PatrickCurran, SarahMcGuffin, PeterDobson, RichardBreen, Gerome2016-08-082016-08-082016-05-05de Jong S, Newhouse SJ, Patel H, Lee S, Dempster D, Curtis C et al. Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis. The British Journal of Psychiatry May 2016, bjp.bp.115.1754710007-1250http://hdl.handle.net/10668/2318JOURNAL ARTICLE;BACKGROUND Recent studies point to overlap between neuropsychiatric disorders in symptomatology and genetic aetiology. AIMS To systematically investigate genomics overlap between childhood and adult attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and major depressive disorder (MDD). METHOD Analysis of whole-genome blood gene expression and genetic risk scores of 318 individuals. Participants included individuals affected with adult ADHD (n = 93), childhood ADHD (n = 17), MDD (n = 63), ASD (n = 51), childhood dual diagnosis of ADHD-ASD (n = 16) and healthy controls (n = 78). RESULTS Weighted gene co-expression analysis results reveal disorder-specific signatures for childhood ADHD and MDD, and also highlight two immune-related gene co-expression modules correlating inversely with MDD and adult ADHD disease status. We find no significant relationship between polygenic risk scores and gene expression signatures. CONCLUSIONS Our results reveal disorder overlap and specificity at the genetic and gene expression level. They suggest new pathways contributing to distinct pathophysiology in psychiatric disorders and shed light on potential shared genomic risk factors.enAtenciónTrastorno por déficit de atención con hiperactividadTrastorno del espectro autistaTrastorno depresivo mayorDiagnóstico dual (Psiquiatría)Redes reguladoras de genesGenómicaHumanosFactores de riesgoTranscriptomaMedical Subject Headings::Named Groups::Persons::Age Groups::AdultMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Psychophysiology::Arousal::AttentionMedical Subject Headings::Psychiatry and Psychology::Mental Disorders::Mental Disorders Diagnosed in Childhood::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with HyperactivityMedical Subject Headings::Psychiatry and Psychology::Mental Disorders::Mood Disorders::Depressive Disorder::Depressive Disorder, MajorMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnosis, Dual (Psychiatry)Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Base Sequence::Regulatory Sequences, Nucleic Acid::Gene Regulatory NetworksMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::GenomicsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk FactorsMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression::Transcription, Genetic::TranscriptomeMedical Subject Headings::Psychiatry and Psychology::Mental Disorders::Mental Disorders Diagnosed in Childhood::Child Development Disorders, Pervasive::Autism Spectrum Disorderresearch article27151072open access10.1192/bjp.bp.115.1754711472- 1465