Somoza, Maria LuisaPerez-Sanchez, NataliaVictorio-Puche, LauraMartin-Pedraza, LauraEsteban Rodriguez, AngelBlanca-Lopez, NataliaAbel-Fernandez Gonzalez, EvaRuano-Zaragoza, MariaPrieto-Moreno-Pfeifer, AnaFernandez-Caldas, EnriqueMoran-Morales, MiriamFernandez-Sanchez, Francisco JavierLopez-Sanchez, Jose DamianJimenez-Rodriguez, Teodorikez WilfoxSubiza-Garrido-Lestache, Jose LuisCanto-Diez, GabrielaBlanca-Gomez, MiguelCornejo-Garcia, Jose Antonio2023-02-092023-02-092021-08-19Somoza ML, Pérez-Sánchez N, Victorio-Puche L, Martín-Pedraza L, Esteban Rodríguez A, Blanca-López N, et al. Subjects develop tolerance to Pru p 3 but respiratory allergy to Pru p 9: A large study group from a peach exposed population. PLoS One. 2021 Aug 19;16(8):e0255305http://hdl.handle.net/10668/18393Peach tree allergens are present in fruit, pollen, branches, and leaves, and can induce systemic, respiratory, cutaneous, and gastrointestinal symptoms. We studied the capacity of peach fruit/Pru p 1, Pru p 3, Pru p 4, Pru p 7 and peach pollen/Pru p 9 for inducing symptoms following oral or respiratory exposure in a large group of subjects. We included 716 adults (aged 21 to 83 y.o.) exposed to peach tree pollen and fruit intake in the study population. Participants completed a questionnaire and were skin tested with a panel of inhalant and food allergens, including peach tree pollen, Pru p 9 and peach fruit skin extract. Immunoglobulin E antibodies (SIgE) to Pru p 1, Pru p 3, Pru p 4 and Pru p 7 were quantified. Sensitised subjects underwent oral food challenge with peach fruit and nasal provocation test with peach tree pollen and Pru p 9. The prevalence of sensitisation to peach fruit was 5% and most of these had SIgE to Pru p 3, with a very low proportion to Pru p 4 SIgE and no SIgE to Pru p 1 and Pru p 7. In only 1.8%, anaphylaxis was the clinical entity induced. Cases with positive skin tests to peach and SIgE to Pru p 3 presented a good tolerance after oral challenge with peach fruit. The prevalence of skin sensitisation to peach tree pollen was 22%, with almost half recognising Pru p 9. This induced respiratory symptoms in those evaluated by nasal provocation. In a large population group exposed to peach fruit and peach tree pollen, most individuals were tolerant, even in those with SIgE to Pru p 3. A positive response to Pru p 9 was associated with respiratory allergy.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Population GroupsPrunus persicaYoung AdultAdultAllergensFood HypersensitivityHumansMiddle Agedresearch article34411133open accessFrutasPolenPielAlérgenosAnafilaxiaPruebas de provocación nasalPruebas cutáneas10.1371/journal.pone.02553051932-6203PMC8376049https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0255305&type=printablehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376049/pdf