Molina, IreneGonzalvo, María del CarmenClavero, AnaLópez-Ruz, Miguel AngelMozas, JuanPasquau, JuanSampedro, AntonioMartínez, LuisCastilla, José Antonio2014-06-242014-06-242014-01Molina I, Gonzalvo MC, Clavero A, López-Ruz MA, Mozas J, Pasquau J, et al. Assisted reproductive technology and obstetric outcome in couples when the male partner has a chronic viral disease. Int J Fertil Steril . 2014 Jan-Mar; 7(4): 291–3002008-0778http://hdl.handle.net/10668/1648Journal Article;BACKGROUND Assisted reproductive technology (ART) with washed semen can achieve pregnancy with minimal risk of horizontal and vertical transmission of chronic viral diseases (CVD) such as human immunodeficiency virus (HIV), hepati- tis C virus (HCV) and hepatitis B virus (HBV) among serodiscordant couples. How- ever, few studies have been made of the use made by these couples of ARTs or of the obstetric results achieved. MATERIALS AND METHODS In this retrospective study, 93 men who were seropositive for HIV, HCV or HBV and who underwent assisted reproduction treatment at our centre (Hospital Universitario Virgen de las Nieves, Granada, Spain) were included. Washed semen was tested to detect viral particles. Non-infected women were tested before and after each treatment, as were the neonates at birth and after three months. RESULTS A total of 62 sperm samples were washed, and none were positive for the detec- tion of viral molecules. Semen samples from 34 HBV positive males were not washed since the female partner had immunity to hepatitis B. In total, 38 clinical pregnancies were achieved (22% per cycle and 40.9% per couple) out of 173 cycles initiated, and 28 births were achieved (16.2% per cycle and 30.1% per couple), producing 34 live births. The rate of multiple pregnancies was 21.4%. Obstetric and neonatal results were similar in the groups of couples studied. At follow-up, no seroconversion was detected in the women or neonates. CONCLUSION Sperm washing and intracytoplasmic sperm injection are shown to be a safe and effective option for reducing the risk of transmission or super infection in serodiscordant or concordant couples who wish to have a child. Pregnancies ob- tained by ART in couples when the male is CVD infected achieve good obstetric and neonatal results.enHIVHCVHBVReproductive techniquesObstetric labor complicationsInfecciones por VIHFertilidadSeropositividad para VIHTécnicas reproductivasComplicaciones del trabajo de partoInyecciones de esperma intracitoplasmáticasAnticuerpos contra la Hepatitis hAnticuerpos contra la hepatitis CMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::FertilityMedical Subject Headings::Diseases::Immune System Diseases::Immunologic Deficiency Syndromes::HIV InfectionsMedical Subject Headings::Diseases::Immune System Diseases::Immunologic Deficiency Syndromes::HIV Infections::HIV SeropositivityMedical Subject Headings::Check Tags::MaleMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::PregnancyMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk FactorsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Reproductive Techniques::Reproductive Techniques, Assisted::Fertilization in Vitro::Sperm Injections, IntracytoplasmicMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Disease Transmission, Infectious::Infectious Disease Transmission, VerticalMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Reproductive Techniques::Reproductive Techniques, AssistedMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Viral::Hepatitis Antibodies::Hepatitis B AntibodiesMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Viral::Hepatitis Antibodies::Hepatitis C AntibodiesMedical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy ComplicationsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Pregnancy Outcomeresearch article24520499open access2008-076XPMC3901182