Leśniak, WiktoriaMorbidoni, LauraDicker, DrorMarín-León, IgnacioEFIM2025-01-072025-01-072020-05-29https://hdl.handle.net/10668/26860The rising number of clinical guidelines poses a new challenge to the internists. The main problems are: 1) available documents suffer from heterogeneous methodological quality, and 2) most of clinical guidelines target an 'ideal' patient affected by a single condition, while in real practice internists must face with comorbid patients typically undergoing a polypharmacy. To help address this challenge, EFIM Clinical Practice Working Group started a project aimed to answer a series of relevant clinical questions, by selecting the best available guidance containing recommendations applicable to complex patients under polypharmacy. The project started with the creation of a research protocol containing details about all the steps needed to write the Clinical Practice Guideline Summary. In particular, this methodological document specifies the rules: 1) to select topics and clinical questions; 2) to build up a panel of experts, carefully managing eventual conflict of interests; 3) to critically appraise clinical guidelines (using a validated tool as AGREE II), selecting the most valid and applicable to the common clinical practice (using ADAPTE; 4) to address and solve potential disagreements among the selected documents.enClinical practice guidelinesGuideline adaptationInternal medicineInternistsMultimorbidityHumansInternal MedicinePolypharmacyPractice Guidelines as Topicresearch article32482600open access10.1016/j.ejim.2020.05.0161879-0828http://www.ejinme.com/article/S0953620520302028/pdf